Levamisole refers to Levo tetramisole, it is the Levo Isomer of tetramisole. It can selectively inhibit succinate dehydrogenase in parasite’s muscle so as to stop the reduction of succinic acid from fumaric acid. Therefore the parasite’s muscle metabolism lacks of oxygen and leads to decreasing of energy.
L-isomer is active against helminthes with 1-2 times higher active efficiency and lower toxic and side effects than tetramisole. It is a broad spectrum anthelmintic with a very good activity against roundworms, hookworms, whipworms, and strongyloises stercoralis. It is an immunomodulator and has effect on rheumatic disorders.
Levamisole is also a good alternative in cases of benzimidazole resistance.