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| Identification |
| Molecular Structure |
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CAS No. |
157810-81-6 |
| Molecular Formula |
C36H47N5O4.H2SO4 |
| Molecular Weight |
711.87 |
| Name |
Indinavir sulfate |
| Synonymous |
(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide sulfate |
| Properties |
| Melting Point |
N/A
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| Safety & Transportation Information |
| Harzard Symbols |
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| Hs code |
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| Supplier Specification |
| Appearance |
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| Purity |
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| Packages |
25kg/drum
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| Productivity |
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| Storage |
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| Notes |
Mechanism of action: HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme.This inhibition prevents cleavage of the viral polyproteins resulting in formation of immature non-infectious viral particles.
Indication and usage: Indinavir in combination with antiretroviral agents is indicated for the treatment of HIV infection. This indication is based on two clinical trials of approximately 1 year duration that demonstrated: 1) a reduction in the risk of AIDS-defining illnesses or death; 2) a prolonged suppression of HIV RNA.
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